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Crystal structure of rabex-5 cc domain
Analyse Crystal structure of rabex-5 cc domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N3X
- Type
- protein
- Length
- 195 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAB5 GDP/GTP exchange factor
- UniProt
- Q9UJ41
- Pockets
- 2 · best druggability 0.86
Structure
x-ray diffraction · 3 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | RAB5 GDP/GTP exchange factor | protein | 49 | 94% helix, 0% strand | Q9UJ41 |
| B | RAB5 GDP/GTP exchange factor | protein | 51 | 96% helix, 0% strand | Q9UJ41 |
| C | RAB5 GDP/GTP exchange factor | protein | 46 | 89% helix, 0% strand | Q9UJ41 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.86 | 0.95 | 41 | empty |
| 2 | 108 | 0.72 | 0.93 | 22 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1009 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 916 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 909 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 887 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 282 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UJ41
- Elsewhere: RCSB PDB 4N3X · PDBe 4N3X · UniProt Q9UJ41
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