Research workbench
Structural evidence for antigen receptor evolution
Analyse Structural evidence for antigen receptor evolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N1C
- Type
- protein
- Length
- 330 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin variable light chain domain; Lysozyme C
- EC
- 3.2.1.17
- UniProt
- P00698
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Immunoglobulin variable light chain domain | protein | 107 | 3% helix, 50% strand | — |
| B | Immunoglobulin variable light chain domain | protein | 106 | 3% helix, 49% strand | — |
| C | Lysozyme C (EC 3.2.1.17) | protein | 117 | 44% helix, 10% strand | P00698 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.72 | 0.97 | 21 | empty |
| 2 | 87 | 0.56 | 0.86 | 17 | empty |
| 3 | 61 | 0.32 | 0.76 | 12 | empty |
| 4 | 58 | 0.26 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 734 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 431 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 310 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 4N1C · Structural evidence for antigen receptor evolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00698
- Elsewhere: RCSB PDB 4N1C · PDBe 4N1C · UniProt P00698
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