Research workbench

Interferon regulatory factor 1 (irf-1) complex with DNA

Analyse Interferon regulatory factor 1 (irf-1) complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IF1
Type: protein + DNA
Length: 261 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (26-mer); Protein (interferon regulatory factor 1)
UniProt: P15314
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 3 distinct chains · 29% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, D	DNA (26-mer)	dna	26	—	—
A	Protein (interferon regulatory factor 1)	protein	105	30% helix, 8% strand	P15314
B	Protein (interferon regulatory factor 1)	protein	104	29% helix, 6% strand	P15314

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	146	0.59	0.84	25	empty
2	228	0.57	0.79	26	empty
3	76	0.38	0.78	13	empty
4	66	0.33	0.76	15	empty
5	56	0.32	0.77	10	empty

Interfaces

5 interfaces between chains.

D–B · 1010 Å² buried · 23 hydrogen bonds · protein-nucleic
C–A · 981 Å² buried · 20 hydrogen bonds · protein-nucleic
C–D · 214 Å² buried · 4 hydrogen bonds · nucleic-nucleic
D–A · 85 Å² buried · 0 hydrogen bonds · protein-nucleic
C–B · 67 Å² buried · 0 hydrogen bonds · protein-nucleic

Compared structures

1IF1 · Interferon regulatory factor 1 (irf-1) complex with DNA · the same entry in another collection · chain C against C, TM-score 1.00
P15314 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 1 (P15314) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15314
Elsewhere: RCSB PDB 1IF1 · PDBe 1IF1 · UniProt P15314

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