Research workbench
Crystal structure of the aromatic amino acid aminotransferase from streptococcus mutants
Analyse Crystal structure of the aromatic amino acid aminotransferase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MY5
- Type
- protein
- Length
- 1,537 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative amino acid aminotransferase
- UniProt
- Q8DWM1
- Pockets
- 14 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative amino acid aminotransferase | protein | 390 | 43% helix, 14% strand | Q8DWM1 |
| D | Putative amino acid aminotransferase | protein | 377 | 45% helix, 16% strand | Q8DWM1 |
| B | Putative amino acid aminotransferase | protein | 382 | 45% helix, 15% strand | Q8DWM1 |
| C | Putative amino acid aminotransferase | protein | 388 | 44% helix, 14% strand | Q8DWM1 |
Pockets
14 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.83 | 0.84 | 107 | empty |
| 2 | 1077 | 0.82 | 0.83 | 98 | empty |
| 3 | 847 | 0.75 | 0.79 | 84 | empty |
| 4 | 889 | 0.74 | 0.78 | 74 | empty |
| 5 | 116 | 0.64 | 0.88 | 26 | empty |
Interfaces
3 interfaces between chains.
- D–C · 2799 Ų buried · 31 hydrogen bonds · protein-protein
- A–B · 2652 Ų buried · 31 hydrogen bonds · protein-protein
- A–D · 18 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4MY5 · Crystal structure of the aromatic amino acid aminotransferase from Streptococcus mutants · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DWM1
- Elsewhere: RCSB PDB 4MY5 · PDBe 4MY5 · UniProt Q8DWM1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.