Research workbench
Crystal structure of superantigen pfit
Analyse Crystal structure of superantigen pfit in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MXM
- Type
- protein
- Length
- 376 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator I2
- UniProt
- I2BPL4
- Pockets
- 6 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator I2 | protein | 199 | 72% helix, 0% strand | I2BPL4 |
| B | Transcriptional regulator I2 | protein | 177 | 75% helix, 0% strand | I2BPL4 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.60 | 0.91 | 27 | empty |
| 2 | 341 | 0.58 | 0.76 | 31 | empty |
| 3 | 295 | 0.57 | 0.76 | 26 | empty |
| 4 | 146 | 0.47 | 0.77 | 18 | empty |
| 5 | 161 | 0.44 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1162 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 4MXM · Crystal structure of superantigen pfit · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I2BPL4
- Elsewhere: RCSB PDB 4MXM · PDBe 4MXM · UniProt I2BPL4
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