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Human methyltransferase-like protein 21C

Analyse Human methyltransferase-like protein 21C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4MTL
Type: protein
Length: 427 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-lysine methyltransferase METTL21C
EC: 2.1.1.-
UniProt: Q5VZV1
Ligands: SAH, UNX
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-lysine methyltransferase METTL21C (EC 2.1.1.-)	protein	208	33% helix, 28% strand	Q5VZV1
B	Protein-lysine methyltransferase METTL21C (EC 2.1.1.-)	protein	219	36% helix, 26% strand	Q5VZV1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · 2 copies · chains A, B
UNX · Unknown atom or ion · ion · 37 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	298	0.76	0.88	44	UNX, SAH
2	171	0.63	0.84	32	SAH

Interfaces

1 interface between chains.

A–B · 902 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4MTL · Human Methyltransferase-Like Protein 21C · the same entry in another collection · chain A against A, TM-score 1.00
Q5VZV1 · AlphaFold monomer V2.0 prediction for protein-lysine methyltransferase METTL21C (Q5VZV1) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5VZV1
Elsewhere: RCSB PDB 4MTL · PDBe 4MTL · UniProt Q5VZV1

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