Research workbench

Structure of the B12-independent glycerol dehydratase with 1,2- propanediol bound

Analyse Structure of the B12-independent glycerol dehydratase with 1,2- propanediol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4MTJ
Type: protein
Length: 1,572 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: B12-independent glycerol dehydratase
UniProt: Q8GEZ8
Pockets: 18 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	B12-independent glycerol dehydratase	protein	786	52% helix, 9% strand	Q8GEZ8

Ligands and binding sites

PGO · S-1,2-propanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	996	0.81	0.82	73	empty
2	205	0.63	0.83	23	empty
3	153	0.59	0.84	30	empty
4	166	0.58	0.82	30	empty
5	178	0.58	0.81	22	empty

Interfaces

1 interface between chains.

A–B · 1263 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4MTJ · Structure of the b12-independent glycerol dehydratase with 1,2-propanediol bound · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8GEZ8
Elsewhere: RCSB PDB 4MTJ · PDBe 4MTJ · UniProt Q8GEZ8

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.