Research workbench
Fructose-bisphosphate aldolase from slackia heliotrinireducens dsm 20476
Analyse Fructose-bisphosphate aldolase from slackia heliotrinireducens dsm 20476 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MOZ
- Type
- protein
- Length
- 1,575 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose-bisphosphate aldolase
- UniProt
- C7N7V8
- Pockets
- 19 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose-bisphosphate aldolase | protein | 316 | 44% helix, 13% strand | C7N7V8 |
| B, E | Fructose-bisphosphate aldolase | protein | 314 | 44% helix, 13% strand | C7N7V8 |
| C | Fructose-bisphosphate aldolase | protein | 318 | 44% helix, 13% strand | C7N7V8 |
| D | Fructose-bisphosphate aldolase | protein | 313 | 45% helix, 13% strand | C7N7V8 |
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 321 | 0.69 | 0.83 | 51 | empty |
| 2 | 338 | 0.69 | 0.82 | 48 | empty |
| 3 | 274 | 0.64 | 0.81 | 34 | empty |
| 4 | 255 | 0.64 | 0.82 | 33 | empty |
| 5 | 290 | 0.63 | 0.80 | 40 | empty |
Interfaces
5 interfaces between chains.
- D–E · 1564 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1563 Ų buried · 26 hydrogen bonds · protein-protein
- A–E · 1563 Ų buried · 26 hydrogen bonds · protein-protein
- B–C · 1561 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1560 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 30 modified (engineered).
Compared structures
- 4MOZ · Fructose-bisphosphate aldolase from Slackia heliotrinireducens DSM 20476 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C7N7V8
- Elsewhere: RCSB PDB 4MOZ · PDBe 4MOZ · UniProt C7N7V8
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