Research workbench
Structure of the DP10.7 TCR
Analyse Structure of the DP10.7 TCR in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MNH
- Type
- protein
- Length
- 863 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-cell receptor gamma chain V region pt-gamma-1/2, human nkt TCR beta chain; Human nkt…
- UniProt
- K7N5M4, Q6PJ56
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 4 distinct chains · 5% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-cell receptor gamma chain V region pt-gamma-1/2, human nkt TCR beta chain | protein | 231 | 7% helix, 48% strand | K7N5M4 |
| B | Human nkt TCR alpha chain | protein | 197 | 2% helix, 41% strand | Q6PJ56 |
| C | T-cell receptor gamma chain V region pt-gamma-1/2, human nkt TCR beta chain | protein | 236 | 7% helix, 48% strand | K7N5M4 |
| D | Human nkt TCR alpha chain | protein | 199 | 3% helix, 42% strand | Q6PJ56 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 968 | 0.71 | 0.76 | 77 | empty |
| 2 | 826 | 0.67 | 0.75 | 67 | empty |
| 3 | 428 | 0.64 | 0.78 | 48 | empty |
| 4 | 71 | 0.43 | 0.80 | 17 | empty |
| 5 | 140 | 0.43 | 0.75 | 28 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2302 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2252 Ų buried · 22 hydrogen bonds · protein-protein
- B–D · 315 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 195 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 27 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 4MNH · Structure of the DP10.7 TCR · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K7N5M4
- Every structure of UniProt Q6PJ56
- Elsewhere: RCSB PDB 4MNH · PDBe 4MNH · UniProt K7N5M4 · UniProt Q6PJ56
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.