Research workbench
Structural and biochemical analysis of type II free methionine-R- sulfoxide reductase from thermoplasma acidophilum
Analyse Structural and biochemical analysis of type II free methionine-R- sulfoxide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4MMN
- Type
- protein
- Length
- 1,124 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein TA0848
- UniProt
- Q9HJW5
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, E, F | Putative uncharacterized protein TA0848 | protein | 141 | 35% helix, 29% strand | Q9HJW5 |
| B, C, G, H | Putative uncharacterized protein TA0848 | protein | 140 | 35% helix, 29% strand | Q9HJW5 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 811 | 0.72 | 0.77 | 42 | empty |
| 2 | 228 | 0.54 | 0.77 | 26 | empty |
| 3 | 179 | 0.45 | 0.75 | 23 | empty |
| 4 | 154 | 0.44 | 0.75 | 22 | empty |
| 5 | 156 | 0.44 | 0.75 | 21 | empty |
Interfaces
7 interfaces between chains.
- F–G · 861 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 840 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 828 Ų buried · 9 hydrogen bonds · protein-protein
- D–E · 402 Ų buried · 5 hydrogen bonds · protein-protein
- C–H · 364 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4MMN · Structural and biochemical analysis of type II free methionine-R-sulfoxide reductase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HJW5
- Elsewhere: RCSB PDB 4MMN · PDBe 4MMN · UniProt Q9HJW5
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