Research workbench
Disulfide isomerase from multidrug resistance INCA/C conjugative plasmid in reduced state
Analyse Disulfide isomerase from multidrug resistance INCA/C conjugative plasmid in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ML6
- Type
- protein
- Length
- 807 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dsbp
- EC
- 5.3.4.1
- UniProt
- A6GV51
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dsbp (EC 5.3.4.1) | protein | 202 | 29% helix, 30% strand | A6GV51 |
| B, D | Dsbp (EC 5.3.4.1) | protein | 201 | 29% helix, 30% strand | A6GV51 |
| C | Dsbp (EC 5.3.4.1) | protein | 203 | 33% helix, 30% strand | A6GV51 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 496 | 0.78 | 0.86 | 87 | empty |
| 2 | 640 | 0.78 | 0.83 | 73 | empty |
| 3 | 116 | 0.57 | 0.84 | 24 | empty |
| 4 | 246 | 0.56 | 0.78 | 42 | empty |
| 5 | 94 | 0.54 | 0.84 | 19 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2129 Ų buried · 32 hydrogen bonds · protein-protein
- B–D · 2109 Ų buried · 35 hydrogen bonds · protein-protein
- A–B · 1508 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 780 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 374 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4ML6 · Disulfide isomerase from multidrug resistance IncA/C conjugative plasmid in reduced state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6GV51
- Elsewhere: RCSB PDB 4ML6 · PDBe 4ML6 · UniProt A6GV51
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