Research workbench
Mouse glandular kallikrein-13 (prorenin converting enzyme)
Analyse Mouse glandular kallikrein-13 (prorenin converting enzyme) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1AO5
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glandular kallikrein-13
- EC
- 3.4.21.35
- UniProt
- P36368
- Ligands
- NAG
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glandular kallikrein-13 (EC 3.4.21.35) | protein | 236 | 11% helix, 33% strand | P36368 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 979 | 0.78 | 0.80 | 77 | empty |
Interfaces
1 interface between chains.
- A–B · 820 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 1AO5 · Mouse glandular kallikrein-13 (prorenin converting enzyme) · the same entry in another collection · chain A against A, TM-score 1.00
- P36368 · AlphaFold monomer V2.0 prediction for epidermal growth factor-binding protein type B… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36368
- Elsewhere: RCSB PDB 1AO5 · PDBe 1AO5 · UniProt P36368
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