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Caspase-3 specific unnatural amino acid peptides

Analyse Caspase-3 specific unnatural amino acid peptides in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4JJE
Type: protein
Length: 245 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.481
Source: Homo sapiens; SYNTHETIC CONSTRUCT
Molecule: Caspase-3; Caspase inhibitor
EC: 3.4.22.56
UniProt: P42574

Structure

x-ray diffraction · resolution 1.481 · 2 distinct chains · 28% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-3 (EC 3.4.22.56)	protein	240	29% helix, 25% strand	P42574
B	Caspase inhibitor	protein	5	0% helix, 60% strand	—

Interfaces

1 interface between chains.

A–B · 526 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (nonstandard).

Compared structures

4JJE · Caspase-3 specific unnatural amino acid peptides · the same entry in another collection · chain A against A, TM-score 1.00
P42574 · AlphaFold monomer V2.0 prediction for caspase-3 (P42574) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42574
Elsewhere: RCSB PDB 4JJE · PDBe 4JJE · UniProt P42574

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