Research workbench
Deoxychorismate lyase from escherichia COLI with inhibitor
Analyse Deoxychorismate lyase from escherichia COLI with inhibitor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1I2L
- Type
- protein
- Length
- 269 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.3
- Source
- Escherichia coli
- Molecule
- 4-amino-4-deoxychorismate lyase
- EC
- 4.-.-.-
- UniProt
- P28305
- Ligands
- DCS
- Pockets
- 3 · best druggability 0.60
Structure
x-ray diffraction · resolution 2.3 · 1 distinct chain · 28% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 4-amino-4-deoxychorismate lyase (EC 4.-.-.-) | protein | 269 | 28% helix, 30% strand | P28305 |
Ligands and binding sites
- DCS · D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 266 | 0.60 | 0.79 | 34 | DCS |
| 2 | 55 | 0.32 | 0.77 | 11 | empty |
| 3 | 53 | 0.25 | 0.72 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28305
- Elsewhere: RCSB PDB 1I2L · PDBe 1I2L · UniProt P28305
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