Research workbench
Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from Caenorhadbitis elegans in P1 space group
Analyse Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from Caenorhadbitis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4J0E
- Type
- protein
- Length
- 579 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.6
- Source
- Caenorhabditis elegans
- Molecule
- Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1
- EC
- 1.1.1.35
- UniProt
- P34439
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · resolution 1.6 · 2 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC 1.1.1.35) | protein | 296 | 52% helix, 14% strand | P34439 |
| B | Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1 (EC 1.1.1.35) | protein | 283 | 50% helix, 15% strand | P34439 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 396 | 0.65 | 0.79 | 44 | empty |
| 2 | 374 | 0.64 | 0.79 | 41 | empty |
| 3 | 151 | 0.43 | 0.75 | 27 | empty |
| 4 | 53 | 0.42 | 0.83 | 18 | empty |
| 5 | 52 | 0.39 | 0.81 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1732 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4J0E · Crystal structure of 3-hydroxyacyl-CoA dehydrogenase from caenorhadbitis elegans in P1… · the same entry in another collection · chain A against A, TM-score 1.00
- P34439 · AlphaFold monomer V2.0 prediction for probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34439
- Elsewhere: RCSB PDB 4J0E · PDBe 4J0E · UniProt P34439
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