Research workbench
Crystal structure of ectodomain 3 of the IL-13 receptor alpha1 in complex with a human neutralizing monoclonal antibody fragment
Analyse Crystal structure of ectodomain 3 of the IL-13 receptor alpha1 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HWE
- Type
- protein
- Length
- 423 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.43
- Source
- Homo sapiens
- Molecule
- Fab heavy chain; Fab light chain
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · resolution 2.43 · 2 distinct chains · 9% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Fab heavy chain | protein | 213 | 9% helix, 51% strand | — |
| L | Fab light chain | protein | 210 | 8% helix, 53% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 388 | 0.57 | 0.75 | 44 | empty |
| 2 | 60 | 0.31 | 0.75 | 15 | GOL |
| 3 | 72 | 0.30 | 0.73 | 15 | GOL |
| 4 | 75 | 0.29 | 0.72 | 21 | GOL |
Interfaces
1 interface between chains.
- H–L · 1638 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4HWE · Crystal structure of ectodomain 3 of the il-13 receptor ALPHA1 in complex with a human… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4HWE · PDBe 4HWE
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