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Human EphA3 Kinase domain in complex with ligand 90

Analyse Human EphA3 Kinase domain in complex with ligand 90 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GK4
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.1
Source: Homo sapiens
Molecule: EPH receptor A3
EC: 2.7.10.1
UniProt: Q6P4R6
Ligands: L90
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · resolution 2.1 · 1 distinct chain · 39% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	EPH receptor A3 (EC 2.7.10.1)	protein	275	39% helix, 19% strand	Q6P4R6

Ligands and binding sites

L90 · 8-butyl-1-methyl-7-(5-methyl-1H-indazol-4-yl)-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	312	0.61	0.78	31	L90

Compared structures

4GK4 · Human EPHA3 kinase domain in complex with ligand 90 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6P4R6
Elsewhere: RCSB PDB 4GK4 · PDBe 4GK4 · UniProt Q6P4R6

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