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Crystal Structure of D48V||A47D mutant of Human GLTP bound with 12:0 monosulfatide
Analyse Crystal Structure of D48V||A47D mutant of Human GLTP bound with 12:0… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GHP
- Type
- protein
- Length
- 202 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Homo sapiens
- Molecule
- Glycolipid transfer protein
- UniProt
- Q9NZD2
- Ligands
- EIS
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · resolution 1.9 · 1 distinct chain · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycolipid transfer protein | protein | 202 | 68% helix, 2% strand | Q9NZD2 |
Ligands and binding sites
- EIS · N-{(2S,3R,4E)-3-hydroxy-1-[(3-O-sulfo-beta-D-galactopyranosyl)oxy]octadec-4-en-2-yl}dodecanamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 530 | 0.75 | 0.82 | 47 | EIS |
| 2 | 55 | 0.50 | 0.86 | 13 | empty |
Compared structures
- 4GHP · Crystal structure of D48V||A47D mutant of human gltp bound with 12:0 monosulfatide · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NZD2 · AlphaFold monomer V2.0 prediction for glycolipid transfer protein (Q9NZD2) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZD2
- Elsewhere: RCSB PDB 4GHP · PDBe 4GHP · UniProt Q9NZD2
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