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Crystal structure of the atypical phosphoinositide (aPI) binding domain of IQGAP2

Analyse Crystal structure of the atypical phosphoinositide (aPI) binding domain of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4EZA
Type: protein
Length: 188 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.5
Source: Homo sapiens
Molecule: Ras GTPase-activating-like protein IQGAP2
UniProt: Q13576
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · resolution 1.5 · 1 distinct chain · 33% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ras GTPase-activating-like protein IQGAP2	protein	94	33% helix, 44% strand	Q13576

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.42	0.80	13	empty
2	73	0.42	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 500 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

4EZA · Crystal structure of the atypical phosphoinositide (api) binding domain of IQGAP2 · the same entry in another collection · chain A against A, TM-score 1.00
Q13576 · AlphaFold monomer V2.0 prediction for RAS GTPase-activating-like protein IQGAP2 (Q13576) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13576
Elsewhere: RCSB PDB 4EZA · PDBe 4EZA · UniProt Q13576

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