Research workbench
ENY2:GANP complex
Analyse ENY2:GANP complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DHX
- Type
- protein
- Length
- 508 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Homo sapiens
- Molecule
- 80 kDa MCM3-associated protein; Enhancer of yellow 2 transcription factor homolog
- UniProt
- O60318, Q9NPA8
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · resolution 2.1 · 5 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 80 kDa MCM3-associated protein | protein | 72 | 90% helix, 0% strand | O60318 |
| B, F | Enhancer of yellow 2 transcription factor homolog | protein | 91 | 85% helix, 0% strand | Q9NPA8 |
| C | Enhancer of yellow 2 transcription factor homolog | protein | 93 | 82% helix, 0% strand | Q9NPA8 |
| D | 80 kDa MCM3-associated protein | protein | 69 | 97% helix, 0% strand | O60318 |
| E | Enhancer of yellow 2 transcription factor homolog | protein | 92 | 84% helix, 0% strand | Q9NPA8 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 538 | 0.68 | 0.78 | 63 | empty |
| 2 | 446 | 0.59 | 0.74 | 38 | empty |
Interfaces
9 interfaces between chains.
- D–E · 1559 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1524 Ų buried · 9 hydrogen bonds · protein-protein
- D–F · 1488 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 1474 Ų buried · 4 hydrogen bonds · protein-protein
- B–F · 353 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4DHX · ENY2:GANP complex · the same entry in another collection · chain F against F, TM-score 1.00
- Q9NPA8 · AlphaFold monomer V2.0 prediction for transcription and mRNA export factor ENY2 (Q9NPA8) · a predicted model of the same protein · chain E against A, TM-score 0.96
- O60318 · AlphaFold monomer V2.0 prediction for germinal-center associated nuclear protein (O60318) · a predicted model of the same protein · chain D against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60318
- Every structure of UniProt Q9NPA8
- Elsewhere: RCSB PDB 4DHX · PDBe 4DHX · UniProt O60318 · UniProt Q9NPA8
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