Research workbench
The structure of Pyrococcus Furiosus SfsA in complex with DNA
Analyse The structure of Pyrococcus Furiosus SfsA in complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4DAV
- Type
- protein + DNA
- Length
- 486 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Pyrococcus furiosus; SYNTHETIC CONSTRUCT
- Molecule
- Sugar fermentation stimulation protein homolog…
- UniProt
- Q8U1K8
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · resolution 2.2 · 2 distinct chains · 19% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Sugar fermentation stimulation protein homolog | protein | 231 | 19% helix, 44% strand | Q8U1K8 |
| X, D | 5'-D(*CP*GP*CP*TP*GP*TP*CP*TP*CP*GP*CP*T)-3' | dna | 12 | — | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 529 | 0.76 | 0.84 | 51 | empty |
| 2 | 556 | 0.75 | 0.83 | 55 | empty |
| 3 | 85 | 0.34 | 0.75 | 17 | empty |
Interfaces
5 interfaces between chains.
- B–D · 487 Ų buried · 9 hydrogen bonds · protein-nucleic
- B–X · 486 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–D · 471 Ų buried · 13 hydrogen bonds · protein-nucleic
- A–X · 461 Ų buried · 11 hydrogen bonds · protein-nucleic
- X–D · 417 Ų buried · 34 hydrogen bonds · nucleic-nucleic
Compared structures
- 4DAV · The structure of pyrococcus furiosus sfsa in complex with DNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q8U1K8 · AlphaFold monomer V2.0 prediction for sugar fermentation stimulation protein homolog… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8U1K8
- Elsewhere: RCSB PDB 4DAV · PDBe 4DAV · UniProt Q8U1K8
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