Research workbench

Candida albicans PKh Kinase Domain

Analyse Candida albicans PKh Kinase Domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4C0T
Type: protein
Length: 291 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.16
Source: CANDIDA ALBICANS
Molecule: Likely protein kinase
EC: 2.7.11.1
UniProt: Q5A3P6
Pockets: 2 · best druggability 0.69

Structure

x-ray diffraction · resolution 3.16 · 1 distinct chain · 36% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Likely protein kinase (EC 2.7.11.1)	protein	291	36% helix, 16% strand	Q5A3P6

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	441	0.69	0.80	42	empty
2	80	0.34	0.75	15	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4C0T · Candida albicans pkh kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q5A3P6 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PKH2 (Q5A3P6) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5A3P6
Elsewhere: RCSB PDB 4C0T · PDBe 4C0T · UniProt Q5A3P6

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