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Crystal structure of the PEPTIDE(PRO-pro-GLY)3 bound complex of N- terminal domain and peptide substrate binding domain of prolyl-4 hydroxylase (residues 1-244) type I from human
Analyse Crystal structure of the PEPTIDE(PRO-pro-GLY)3 bound complex of N- terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4BTA
- Type
- protein
- Length
- 457 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.95
- Source
- HOMO SAPIENS
- Molecule
- Prolyl 4-hydroxylase subunit alpha-1; Proline rich peptide
- EC
- 1.14.11.2
- UniProt
- P13674
- Pockets
- 7 · best druggability 0.47
Structure
x-ray diffraction · resolution 2.95 · 3 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolyl 4-hydroxylase subunit alpha-1 (EC 1.14.11.2) | protein | 237 | 80% helix, 0% strand | P13674 |
| B | Prolyl 4-hydroxylase subunit alpha-1 (EC 1.14.11.2) | protein | 211 | 83% helix, 0% strand | P13674 |
| C | Proline rich peptide | protein | 9 | 0% helix, 0% strand | — |
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.47 | 0.74 | 25 | empty |
| 2 | 90 | 0.42 | 0.78 | 13 | empty |
| 3 | 57 | 0.41 | 0.82 | 18 | empty |
| 4 | 105 | 0.39 | 0.75 | 20 | empty |
| 5 | 104 | 0.34 | 0.73 | 20 | empty |
Interfaces
2 interfaces between chains.
- A–B · 3498 Ų buried · 33 hydrogen bonds · protein-protein
- A–C · 452 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4BTA · Crystal structure of the PEPTIDE(PRO-pro-GLY)3 bound complex of N- terminal domain and… · the same entry in another collection · chain A against A, TM-score 1.00
- P13674 · AlphaFold monomer V2.0 prediction for prolyl 4-hydroxylase subunit alpha-1 (P13674) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13674
- Elsewhere: RCSB PDB 4BTA · PDBe 4BTA · UniProt P13674
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