Research workbench

Aglycosylated human igg1 fc fragment

Analyse Aglycosylated human igg1 fc fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3S7G
Type: protein
Length: 830 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 3.13
Source: Homo sapiens
Molecule: Ig gamma-1 chain C region
UniProt: P01857
Pockets: 13 · best druggability 0.69

Structure

x-ray diffraction · resolution 3.13 · 4 distinct chains · 11% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ig gamma-1 chain C region	protein	208	11% helix, 48% strand	P01857
B	Ig gamma-1 chain C region	protein	207	11% helix, 47% strand	P01857
C	Ig gamma-1 chain C region	protein	208	11% helix, 48% strand	P01857
D	Ig gamma-1 chain C region	protein	207	11% helix, 47% strand	P01857

Pockets

13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.69	0.96	14	empty
2	263	0.55	0.77	24	empty
3	179	0.50	0.77	24	empty
4	155	0.43	0.75	22	empty
5	121	0.37	0.74	21	empty

Interfaces

3 interfaces between chains.

A–B · 1267 Å² buried · 9 hydrogen bonds · protein-protein
C–D · 1159 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 1002 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

3S7G · Aglycosylated human IGG1 Fc fragment · the same entry in another collection · chain D against D, TM-score 1.00
P01857 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy constant gamma 1 (P01857) · a predicted model of the same protein · chain D against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01857
Elsewhere: RCSB PDB 3S7G · PDBe 3S7G · UniProt P01857

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.