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Crystal structure of mouse PERK kinase domain

Analyse Crystal structure of mouse PERK kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3QD2
Type: protein
Length: 272 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.81
Source: Mus musculus
Molecule: Eukaryotic translation initiation factor 2-alpha kinase 3
EC: 2.7.11.1
UniProt: Q9Z2B5
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · resolution 2.81 · 1 distinct chain · 43% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1)	protein	272	43% helix, 18% strand	Q9Z2B5

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.66	0.87	24	empty
2	97	0.43	0.79	25	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

3QD2 · Crystal structure of mouse perk kinase domain · the same entry in another collection · chain B against B, TM-score 1.00
Q9Z2B5 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 2-alpha… · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Z2B5
Elsewhere: RCSB PDB 3QD2 · PDBe 3QD2 · UniProt Q9Z2B5

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