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The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-1-12 DNA
Analyse The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OSG
- Type
- protein + DNA
- Length
- 261 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.997
- Source
- Trichomonas vaginalis; SYNTHETIC CONSTRUCT
- Molecule
- MYB21; 5'-D(*AP*AP*AP*TP*AP*TP*CP*GP*TP*TP*AP*T)-3'…
- UniProt
- Q58HP3
- Pockets
- 8 · best druggability 0.65
Structure
x-ray diffraction · resolution 1.997 · 4 distinct chains · 61% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MYB21 | protein | 110 | 59% helix, 2% strand | Q58HP3 |
| B, E | 5'-D(*AP*AP*AP*TP*AP*TP*CP*GP*TP*TP*AP*T)-3' | dna | 12 | — | — |
| C, F | 5'-D(*AP*TP*AP*AP*CP*GP*AP*TP*AP*TP*TP*T)-3' | dna | 12 | — | — |
| D | MYB21 | protein | 103 | 63% helix, 0% strand | Q58HP3 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.65 | 0.92 | 21 | empty |
| 2 | 76 | 0.64 | 0.92 | 21 | empty |
| 3 | 86 | 0.43 | 0.80 | 18 | empty |
| 4 | 99 | 0.42 | 0.78 | 16 | empty |
| 5 | 97 | 0.38 | 0.76 | 17 | empty |
Interfaces
7 interfaces between chains.
- A–B · 697 Ų buried · 15 hydrogen bonds · protein-nucleic
- D–E · 672 Ų buried · 13 hydrogen bonds · protein-nucleic
- A–C · 660 Ų buried · 14 hydrogen bonds · protein-nucleic
- D–F · 639 Ų buried · 12 hydrogen bonds · protein-nucleic
- E–F · 527 Ų buried · 40 hydrogen bonds · nucleic-nucleic
Compared structures
- 3OSG · The structure of protozoan parasite trichomonas vaginalis MYB2 in complex with mre-1-12… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q58HP3
- Elsewhere: RCSB PDB 3OSG · PDBe 3OSG · UniProt Q58HP3
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