Research workbench
Native crystal structure of Trichoderma reesei beta-galactosidase
Analyse Native crystal structure of Trichoderma reesei beta-galactosidase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OG2
- Type
- protein
- Length
- 986 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.2
- Source
- Trichoderma reesei
- Molecule
- Beta-galactosidase
- EC
- 3.2.1.23
- UniProt
- Q70SY0
- Ligands
- MAN, NAG, BMA, GLC
- Pockets
- 7 · best druggability 0.56
Structure
x-ray diffraction · resolution 1.2 · 1 distinct chain · 15% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Beta-galactosidase (EC 3.2.1.23) | protein | 986 | 15% helix, 32% strand | Q70SY0 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 11 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains A
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.56 | 0.82 | 20 | empty |
| 2 | 124 | 0.56 | 0.83 | 26 | empty |
| 3 | 89 | 0.50 | 0.83 | 18 | empty |
| 4 | 74 | 0.39 | 0.78 | 19 | GOL |
| 5 | 61 | 0.35 | 0.78 | 20 | empty |
Modifications
Observed in the structure: 5 glycan, 1 disulfide (N-glycosylation, disulfide).
Compared structures
- 3OG2 · Native crystal structure of trichoderma reesei beta-galactosidase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q70SY0
- Elsewhere: RCSB PDB 3OG2 · PDBe 3OG2 · UniProt Q70SY0
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