Research workbench
A mutant human Prolactin receptor antagonist H30A in complex with the extracellular domain of the human prolactin receptor
Analyse A mutant human Prolactin receptor antagonist H30A in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3N0P
- Type
- protein
- Length
- 392 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Homo sapiens
- Molecule
- Prolactin; Prolactin receptor
- UniProt
- P01236, P16471
- Ligands
- NA, CL
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · resolution 2.1 · 2 distinct chains · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prolactin | protein | 186 | 74% helix, 0% strand | P01236 |
| B | Prolactin receptor | protein | 206 | 3% helix, 46% strand | P16471 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.55 | 0.86 | 16 | empty |
| 2 | 238 | 0.53 | 0.77 | 38 | empty |
| 3 | 121 | 0.44 | 0.77 | 21 | empty |
| 4 | 113 | 0.42 | 0.77 | 24 | empty |
| 5 | 73 | 0.38 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1245 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3N0P · A mutant human prolactin receptor antagonist H30A in complex with the extracellular… · the same entry in another collection · chain A against A, TM-score 1.00
- P16471 · AlphaFold monomer V2.0 prediction for prolactin receptor (P16471) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P01236 · AlphaFold monomer V2.0 prediction for prolactin (P01236) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01236
- Every structure of UniProt P16471
- Elsewhere: RCSB PDB 3N0P · PDBe 3N0P · UniProt P01236 · UniProt P16471
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