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Drosophila MSL3 chromodomain

Analyse Drosophila MSL3 chromodomain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3M9Q
Type: protein
Length: 176 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.29
Source: Drosophila melanogaster
Molecule: Protein male-specific lethal-3
UniProt: P50536
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · resolution 1.29 · 2 distinct chains · 23% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein male-specific lethal-3	protein	89	24% helix, 37% strand	P50536
B	Protein male-specific lethal-3	protein	87	22% helix, 38% strand	P50536

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.57	0.77	30	empty

Interfaces

1 interface between chains.

A–B · 518 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

3M9Q · Drosophila MSL3 chromodomain · the same entry in another collection · chain A against A, TM-score 1.00
P50536 · AlphaFold monomer V2.0 prediction for protein male-specific lethal-3 (P50536) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50536
Elsewhere: RCSB PDB 3M9Q · PDBe 3M9Q · UniProt P50536

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