Research workbench
CRYSTAL STRUCTURE OF RESPONSE REGULATOR (SIGNAL RECEIVER DOMAIN) FROM Bermanella marisrubri
Analyse CRYSTAL STRUCTURE OF RESPONSE REGULATOR (SIGNAL RECEIVER DOMAIN) FROM… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LTE
- Type
- protein
- Length
- 2,873 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Bermanella marisrubri
- Molecule
- Response regulator
- UniProt
- Q1N036
- Ligands
- PO4
- Pockets
- 20 · best druggability 0.69
Structure
x-ray diffraction · resolution 2 · 10 distinct chains · 46% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Response regulator | protein | 118 | 45% helix, 21% strand | Q1N036 |
| B, J, K, S, W | Response regulator | protein | 120 | 46% helix, 21% strand | Q1N036 |
| C, N, T | Response regulator | protein | 119 | 45% helix, 21% strand | Q1N036 |
| D, E, F, H, P | Response regulator | protein | 123 | 47% helix, 20% strand | Q1N036 |
| G | Response regulator | protein | 121 | 45% helix, 21% strand | Q1N036 |
| I | Response regulator | protein | 119 | 48% helix, 22% strand | Q1N036 |
| L, M, R, V, X | Response regulator | protein | 118 | 46% helix, 21% strand | Q1N036 |
| O | Response regulator | protein | 117 | 46% helix, 21% strand | Q1N036 |
| Q | Response regulator | protein | 117 | 46% helix, 18% strand | Q1N036 |
| U | Response regulator | protein | 119 | 45% helix, 19% strand | Q1N036 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 311 | 0.69 | 0.83 | 53 | empty |
| 2 | 292 | 0.69 | 0.84 | 41 | empty |
| 3 | 392 | 0.69 | 0.81 | 58 | empty |
| 4 | 493 | 0.68 | 0.79 | 75 | empty |
| 5 | 384 | 0.65 | 0.79 | 53 | empty |
Interfaces
43 interfaces between chains.
- I–J · 868 Ų buried · 7 hydrogen bonds · protein-protein
- U–V · 855 Ų buried · 4 hydrogen bonds · protein-protein
- W–X · 847 Ų buried · 6 hydrogen bonds · protein-protein
- M–N · 837 Ų buried · 5 hydrogen bonds · protein-protein
- K–L · 832 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3LTE · Crystal structure of response regulator (signal receiver domain) from bermanella… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1N036
- Elsewhere: RCSB PDB 3LTE · PDBe 3LTE · UniProt Q1N036
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