Research workbench
Crystal Structure of Drosophila melanogaster Pur-alpha
Analyse Crystal Structure of Drosophila melanogaster Pur-alpha in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3K44
- Type
- protein
- Length
- 570 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.1
- Source
- Drosophila melanogaster
- Molecule
- Purine-rich binding protein-alpha, isoform B
- UniProt
- Q9V4D9
- Ligands
- CL
- Pockets
- 10 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.1 · 2 distinct chains · 26% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Purine-rich binding protein-alpha, isoform B | protein | 145 | 26% helix, 48% strand | Q9V4D9 |
| B, D | Purine-rich binding protein-alpha, isoform B | protein | 140 | 27% helix, 50% strand | Q9V4D9 |
Ligands and binding sites
- CL · Chloride ion · ion · 8 copies · chains A, B, C, D
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 533 | 0.72 | 0.81 | 41 | empty |
| 2 | 267 | 0.53 | 0.76 | 39 | empty |
| 3 | 194 | 0.52 | 0.78 | 22 | empty |
| 4 | 164 | 0.51 | 0.79 | 21 | empty |
| 5 | 91 | 0.38 | 0.76 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–B · 802 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 793 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 313 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 303 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3K44 · Crystal structure of drosophila melanogaster pur-alpha · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9V4D9
- Elsewhere: RCSB PDB 3K44 · PDBe 3K44 · UniProt Q9V4D9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.