Research workbench
Crystal structure of Tom71 complexed with Hsp82 C-terminal fragment
Analyse Crystal structure of Tom71 complexed with Hsp82 C-terminal fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3FP2
- Type
- protein
- Length
- 488 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.98
- Source
- Saccharomyces cerevisiae; SYNTHETIC CONSTRUCT
- Molecule
- TPR repeat-containing protein YHR117W; ATP-dependent molecular chaperone HSP82
- UniProt
- P38825, P02829
- Ligands
- MG, CL
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · resolution 1.98 · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TPR repeat-containing protein YHR117W | protein | 483 | 77% helix, 0% strand | P38825 |
| Q | ATP-dependent molecular chaperone HSP82 | protein | 5 | 0% helix, 0% strand | P02829 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 480 | 0.61 | 0.75 | 57 | MG |
| 2 | 132 | 0.48 | 0.79 | 22 | empty |
| 3 | 106 | 0.45 | 0.79 | 18 | empty |
| 4 | 103 | 0.42 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- A–Q · 430 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 3FP2 · Crystal structure of TOM71 complexed with HSP82 C-terminal fragment · the same entry in another collection · chain A against A, TM-score 1.00
- P38825 · AlphaFold monomer V2.0 prediction for protein TOM71 (P38825) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P02829 · AlphaFold monomer V2.0 prediction for ATP-dependent molecular chaperone HSP82 (P02829) · a predicted model of the same protein · chain Q against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38825
- Every structure of UniProt P02829
- Elsewhere: RCSB PDB 3FP2 · PDBe 3FP2 · UniProt P38825 · UniProt P02829
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