Research workbench
Crystal structure of the CO(II)-bound glyoxalase I of escherichia COLI
Analyse Crystal structure of the CO(II)-bound glyoxalase I of escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FA6
- Type
- protein
- Length
- 256 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Escherichia coli
- Molecule
- Glyoxalase I
- EC
- 4.4.1.5
- UniProt
- P0AC81
- Ligands
- CO
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · resolution 1.9 · 1 distinct chain · 16% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glyoxalase I (EC 4.4.1.5) | protein | 128 | 16% helix, 44% strand | P0AC81 |
Ligands and binding sites
- CO · Cobalt (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 223 | 0.48 | 0.74 | 28 | empty |
| 2 | 176 | 0.43 | 0.73 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1742 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 1FA6 · Crystal structure of the CO(II)-bound glyoxalase I of escherichia COLI · the same entry in another collection · chain A against A, TM-score 1.00
- P0AC81 · AlphaFold monomer V2.0 prediction for lactoylglutathione lyase (P0AC81) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AC81
- Elsewhere: RCSB PDB 1FA6 · PDBe 1FA6 · UniProt P0AC81
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