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Crystal structure of the human Adenovirus type 7 fiber knob

Analyse Crystal structure of the human Adenovirus type 7 fiber knob in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3EXW
Type: protein
Length: 594 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.75
Source: Human adenovirus 7
Molecule: L5 fiber protein
UniProt: Q5EY45
Pockets: 5 · best druggability 0.82

Structure

x-ray diffraction · resolution 1.75 · 1 distinct chain · 12% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	L5 fiber protein	protein	198	12% helix, 41% strand	Q5EY45

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	477	0.82	0.88	40	empty
2	246	0.54	0.77	40	empty
3	89	0.33	0.74	19	empty
4	80	0.29	0.72	19	empty
5	75	0.28	0.72	16	empty

Interfaces

3 interfaces between chains.

A–B · 1127 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 1123 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 1110 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3EXW · Crystal structure of the human adenovirus type 7 fiber knob · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5EY45
Elsewhere: RCSB PDB 3EXW · PDBe 3EXW · UniProt Q5EY45

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