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Structure of cytochrome F from chlamydomonas reinhardtii

Analyse Structure of cytochrome F from chlamydomonas reinhardtii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1EWH
Type: protein
Length: 753 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 2.35
Source: Chlamydomonas reinhardtii
Molecule: Cytochrome F
UniProt: P23577
Ligands: HEC
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · resolution 2.35 · 1 distinct chain · 10% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Cytochrome F	protein	251	10% helix, 37% strand	P23577

Ligands and binding sites

HEC · Heme C · ligand · 3 copies · chains A, C, B
ACT · Acetate ion · additive · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1189	0.82	0.83	136	HEC
2	169	0.70	0.88	36	HEC
3	69	0.33	0.75	13	empty
4	57	0.33	0.76	12	empty
5	53	0.30	0.75	12	empty

Interfaces

2 interfaces between chains.

A–C · 465 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 156 Å² buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 cofactor (heme c attachment).

Compared structures

1EWH · Structure of cytochrome F from chlamydomonas reinhardtii · the same entry in another collection · chain A against A, TM-score 1.00
P23577 · AlphaFold monomer V2.0 prediction for cytochrome F (P23577) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23577
Elsewhere: RCSB PDB 1EWH · PDBe 1EWH · UniProt P23577

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