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Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase
Analyse Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3BCP
- Type
- protein
- Length
- 496 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.57
- Source
- Bos taurus
- Molecule
- Seminal ribonuclease
- EC
- 3.1.27.5
- UniProt
- P00669
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · resolution 2.57 · 1 distinct chain · 19% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Seminal ribonuclease (EC 3.1.27.5) | protein | 124 | 19% helix, 35% strand | P00669 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1120 | 0.84 | 0.85 | 118 | empty |
| 2 | 224 | 0.62 | 0.82 | 32 | empty |
| 3 | 309 | 0.61 | 0.79 | 35 | empty |
| 4 | 55 | 0.43 | 0.83 | 16 | empty |
| 5 | 104 | 0.40 | 0.76 | 20 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1743 Ų buried · 37 hydrogen bonds · protein-protein
- C–D · 1735 Ų buried · 37 hydrogen bonds · protein-protein
- B–D · 844 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 732 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 272 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide, 8 modified (disulfide, alkylation).
Compared structures
- 3BCP · Crystal structure of the swapped non covalent form of P19A/L28Q/N67D bs-RNase · the same entry in another collection · chain A against A, TM-score 1.00
- P00669 · AlphaFold monomer V2.0 prediction for seminal ribonuclease (P00669) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00669
- Elsewhere: RCSB PDB 3BCP · PDBe 3BCP · UniProt P00669
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