Research workbench
Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity
Analyse Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 316D
- Type
- protein + DNA
- Length
- 26 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3
- Source
- STREPTOMYCES ANTIBIOTICUS; SYNTHETIC CONSTRUCT
- Molecule
- DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3'); 8-fluoro-actinomycin D
Structure
x-ray diffraction · resolution 3 · 2 distinct chains · 0% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3') | dna | 8 | — | — |
| C | 8-fluoro-actinomycin D | protein | 10 | 0% helix, 20% strand | — |
Interfaces
3 interfaces between chains.
- A–B · 367 Ų buried · 22 hydrogen bonds · nucleic-nucleic
- B–C · 263 Ų buried · 5 hydrogen bonds · protein-nucleic
- A–C · 243 Ų buried · 3 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified, 2 d-amino (methylation, D-amino acid).
Compared structures
- 316D · Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti- leukemia activity · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 316D · PDBe 316D
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.