Research workbench
Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic pathway, in complex with its activating partner, EryCII
Analyse Structure of the glycosyltransferase EryCIII from the erythromycin biosynthetic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2YJN
- Type
- protein
- Length
- 745 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.091
- Source
- SACCHAROPOLYSPORA ERYTHRAEA
- Molecule
- Glycosyltransferase; Dtdp-4-keto-6-deoxy-hexose 3,4-isomerase
- UniProt
- O54224, O54225
- Pockets
- 10 · best druggability 0.73
Structure
x-ray diffraction · resolution 3.091 · 2 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glycosyltransferase | protein | 408 | 47% helix, 12% strand | O54224 |
| B | Dtdp-4-keto-6-deoxy-hexose 3,4-isomerase | protein | 337 | 50% helix, 8% strand | O54225 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 684 | 0.73 | 0.79 | 66 | empty |
| 2 | 143 | 0.68 | 0.89 | 30 | empty |
| 3 | 77 | 0.62 | 0.90 | 30 | empty |
| 4 | 199 | 0.62 | 0.83 | 45 | empty |
| 5 | 174 | 0.55 | 0.80 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1472 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2YJN · Structure of the glycosyltransferase eryciii from the erythromycin biosynthetic pathway… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O54224
- Every structure of UniProt O54225
- Elsewhere: RCSB PDB 2YJN · PDBe 2YJN · UniProt O54224 · UniProt O54225
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