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Crystal structure of BTB domain from BTBD6
Analyse Crystal structure of BTB domain from BTBD6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2VKP
- Type
- protein
- Length
- 212 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.9
- Source
- Homo sapiens
- Molecule
- BTB/POZ domain-containing protein 6
- UniProt
- Q96KE9
- Ligands
- K
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · resolution 1.9 · 2 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BTB/POZ domain-containing protein 6 | protein | 103 | 50% helix, 14% strand | Q96KE9 |
| B | BTB/POZ domain-containing protein 6 | protein | 109 | 46% helix, 13% strand | Q96KE9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 238 | 0.51 | 0.75 | 36 | empty |
| 2 | 75 | 0.36 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 414 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96KE9
- Elsewhere: RCSB PDB 2VKP · PDBe 2VKP · UniProt Q96KE9
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