Research workbench
C-terminal DOMAIN(WH2-WH4) of elongation factor selb in complex with secis RNA
Analyse C-terminal DOMAIN(WH2-WH4) of elongation factor selb in complex with secis RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2UWM
- Type
- protein + RNA
- Length
- 442 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.31
- Source
- MOORELLA THERMOACETICA; SYNTHETIC CONSTRUCT
- Molecule
- Selenocysteine-specific elongation factor; 5'-R(*GP*GP*CP*GP*UP*UP*GP*CP*CP*GP…
- UniProt
- Q2RFK4
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · resolution 2.31 · 3 distinct chains · 55% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Selenocysteine-specific elongation factor | protein | 193 | 56% helix, 13% strand | Q2RFK4 |
| B | Selenocysteine-specific elongation factor | protein | 203 | 54% helix, 13% strand | Q2RFK4 |
| C, D | 5'-R(*GP*GP*CP*GP*UP*UP*GP*CP*CP*GP *GP*UP*CP*UP*GP*GP*CP*AP*AP*CP*GP*CP*C)-3' | rna | 23 | — | — |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1188 | 0.72 | 0.76 | 60 | empty |
| 2 | 1064 | 0.69 | 0.74 | 58 | empty |
| 3 | 192 | 0.57 | 0.80 | 22 | empty |
| 4 | 103 | 0.39 | 0.76 | 18 | empty |
| 5 | 62 | 0.39 | 0.80 | 13 | empty |
Interfaces
4 interfaces between chains.
- A–D · 610 Ų buried · 12 hydrogen bonds · protein-nucleic
- B–C · 522 Ų buried · 9 hydrogen bonds · protein-nucleic
- A–C · 473 Ų buried · 19 hydrogen bonds · protein-nucleic
- B–D · 429 Ų buried · 16 hydrogen bonds · protein-nucleic
Compared structures
- 2UWM · C-terminal DOMAIN(WH2-WH4) of elongation factor selb in complex with secis RNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2RFK4
- Elsewhere: RCSB PDB 2UWM · PDBe 2UWM · UniProt Q2RFK4
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