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Human serum transferrin, recombinant N-terminal lobe

Analyse Human serum transferrin, recombinant N-terminal lobe in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1A8E
Type: protein
Length: 329 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.6
Source: Homo sapiens
Molecule: Serum transferrin
UniProt: P02787
Ligands: FE, CO3
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · resolution 1.6 · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serum transferrin	protein	329	36% helix, 22% strand	P02787

Ligands and binding sites

FE · Fe (III) ion · metal · chains A
CO3 · Carbonate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.75	0.89	40	empty
2	94	0.36	0.75	22	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1A8E · Human serum transferrin, recombinant N-terminal lobe · the same entry in another collection · chain A against A, TM-score 1.00
P02787 · AlphaFold monomer V2.0 prediction for serotransferrin (P02787) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02787
Elsewhere: RCSB PDB 1A8E · PDBe 1A8E · UniProt P02787

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