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N-terminal domain of tissue inhibitor of metalloproteinase-2 (N-timp-2), NMR, 49 structures

Analyse N-terminal domain of tissue inhibitor of metalloproteinase-2 (N-timp-2), NMR… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2TMP
Type: protein
Length: 127 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: NOT
Source: Homo sapiens
Molecule: Tissue inhibitor of metalloproteinases-2
UniProt: P16035
Pockets: 1 · best druggability 0.29

Structure

solution nmr · resolution NOT · 1 distinct chain · 0% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tissue inhibitor of metalloproteinases-2	protein	127	0% helix, 10% strand	P16035

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.29	0.76	18	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

2TMP · N-terminal domain of tissue inhibitor of metalloproteinase-2 (N-timp- 2), NMR, 49… · the same entry in another collection · chain A against A, TM-score 1.00
P16035 · AlphaFold monomer V2.0 prediction for metalloproteinase inhibitor 2 (P16035) · a predicted model of the same protein · chain A against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16035
Elsewhere: RCSB PDB 2TMP · PDBe 2TMP · UniProt P16035

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