Research workbench

DJ-1 activation by catechol qui modification

Analyse DJ-1 activation by catechol qui modification in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2R1U
Type: protein
Length: 374 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.5
Source: Homo sapiens
Molecule: Protein DJ-1
UniProt: Q99497
Pockets: 5 · best druggability 0.54

Structure

x-ray diffraction · resolution 1.5 · 1 distinct chain · 42% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein DJ-1	protein	187	42% helix, 21% strand	Q99497

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.54	0.80	29	empty
2	51	0.41	0.82	10	empty
3	59	0.41	0.81	11	empty
4	72	0.38	0.78	18	empty
5	62	0.35	0.78	16	empty

Interfaces

1 interface between chains.

A–B · 1434 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

2R1U · Dj-1 activation by catechol quinone modification · the same entry in another collection · chain A against A, TM-score 1.00
Q99497 · AlphaFold monomer V2.0 prediction for parkinson disease protein 7 (Q99497) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99497
Elsewhere: RCSB PDB 2R1U · PDBe 2R1U · UniProt Q99497

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