Research workbench
Crystal structure of the JUN BZIP homodimer complexed with AP-1 DNA
Analyse Crystal structure of the JUN BZIP homodimer complexed with AP-1 DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H7H
- Type
- protein + DNA
- Length
- 154 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.3
- Source
- Avian sarcoma virus; SYNTHETIC CONSTRUCT
- Molecule
- 5'-D(*CP*GP*TP*CP*GP*AP*TP*GP*AP*CP*TP*CP*AP*TP*CP*GP*AP*CP*G)-3'…
- UniProt
- P05411
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · resolution 2.3 · 3 distinct chains · 93% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | 5'-D(*CP*GP*TP*CP*GP*AP*TP*GP*AP*CP*TP*CP*AP*TP*CP*GP*AP*CP*G)-3' | dna | 19 | — | — |
| Y | 5'-D(*CP*GP*TP*CP*GP*AP*TP*GP*AP*GP*TP*CP*AP*TP*CP*GP*AP*CP*G)-3' | dna | 19 | — | — |
| A, B | Viral jun transforming protein | protein | 58 | 93% helix, 0% strand | P05411 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.68 | 0.86 | 27 | empty |
| 2 | 72 | 0.44 | 0.81 | 14 | empty |
| 3 | 81 | 0.44 | 0.80 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1094 Ų buried · 8 hydrogen bonds · protein-protein
- X–Y · 851 Ų buried · 90 hydrogen bonds · nucleic-nucleic
- X–B · 367 Ų buried · 9 hydrogen bonds · protein-nucleic
- Y–A · 337 Ų buried · 7 hydrogen bonds · protein-nucleic
- Y–B · 328 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 2H7H · Crystal structure of the jun bzip homodimer complexed with ap-1 DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05411
- Elsewhere: RCSB PDB 2H7H · PDBe 2H7H · UniProt P05411
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