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Crystal Structure of the Biotin Carboxylase Subunit, F363A Mutant, of Acetyl-CoA Carboxylase from Escherichia coli.
Analyse Crystal Structure of the Biotin Carboxylase Subunit, F363A Mutant, of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GPW
- Type
- protein
- Length
- 1,780 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Escherichia coli
- Molecule
- Biotin carboxylase
- EC
- 6.3.4.14
- UniProt
- P24182
- Pockets
- 12 · best druggability 0.79
Structure
x-ray diffraction · resolution 2.2 · 4 distinct chains · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Biotin carboxylase (EC 6.3.4.14) | protein | 445 | 33% helix, 27% strand | P24182 |
| B | Biotin carboxylase (EC 6.3.4.14) | protein | 442 | 36% helix, 27% strand | P24182 |
| C | Biotin carboxylase (EC 6.3.4.14) | protein | 446 | 37% helix, 27% strand | P24182 |
| D | Biotin carboxylase (EC 6.3.4.14) | protein | 447 | 36% helix, 27% strand | P24182 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 555 | 0.79 | 0.86 | 55 | empty |
| 2 | 583 | 0.79 | 0.85 | 58 | empty |
| 3 | 471 | 0.64 | 0.77 | 67 | empty |
| 4 | 507 | 0.62 | 0.75 | 66 | empty |
| 5 | 422 | 0.59 | 0.75 | 61 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1255 Ų buried · 31 hydrogen bonds · protein-protein
- A–B · 1249 Ų buried · 32 hydrogen bonds · protein-protein
- B–D · 279 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2GPW · Crystal structure of the biotin carboxylase subunit, F363A mutant, of acetyl-CoA… · the same entry in another collection · chain D against D, TM-score 1.00
- P24182 · AlphaFold monomer V2.0 prediction for biotin carboxylase (P24182) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24182
- Elsewhere: RCSB PDB 2GPW · PDBe 2GPW · UniProt P24182
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