Research workbench
Crystal structure of a B30.2/SPRY domain-containing protein GUSTAVUS in complex with Elongin B and Elongin C
Analyse Crystal structure of a B30.2/SPRY domain-containing protein GUSTAVUS in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FNJ
- Type
- protein
- Length
- 403 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.8
- Source
- Drosophila melanogaster; Mus musculus
- Molecule
- CG2944-PF, isoform F; Transcription elongation factor B polypeptide 2; Transcription…
- UniProt
- Q7KRQ1, P62869, P83940
- Pockets
- 1 · best druggability 0.61
Structure
x-ray diffraction · resolution 1.8 · 3 distinct chains · 21% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CG2944-PF, isoform F | protein | 217 | 12% helix, 41% strand | Q7KRQ1 |
| B | Transcription elongation factor B polypeptide 2 | protein | 98 | 19% helix, 39% strand | P62869 |
| C | Transcription elongation factor B polypeptide 1 | protein | 88 | 47% helix, 15% strand | P83940 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.61 | 0.80 | 35 | empty |
Interfaces
2 interfaces between chains.
- B–C · 994 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 716 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2FNJ · Crystal structure of a B30.2/SPRY domain-containing protein gustavus in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P62869 · AlphaFold monomer V2.0 prediction for elongin-B (P62869) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P83940 · AlphaFold monomer V2.0 prediction for elongin-C (P83940) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7KRQ1
- Every structure of UniProt P62869
- Every structure of UniProt P83940
- Elsewhere: RCSB PDB 2FNJ · PDBe 2FNJ · UniProt Q7KRQ1 · UniProt P62869 · UniProt P83940
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.