Research workbench
Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image Reconstruction of the virion at 7.0-A Resolution
Analyse Features of Reovirus Outer-Capsid Protein mu1 Revealed by Electron and Image… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CSE
- Type
- protein
- Length
- 16,111 residues
- Chains
- 27
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 7.0
- Source
- Mammalian orthoreovirus 1; Mammalian orthoreovirus 3
- Molecule
- major outer-capsid protein mu1; major capsid surface protein sigma-3…
- UniProt
- P11077, P07939, P11079, Q9WAB2, P11314, P17376
- Pockets
- 20 · best druggability 0.44
Structure
electron microscopy · resolution 7.0 · 7 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, P, Q, R, J, K, L, T | major outer-capsid protein mu1 | protein | 641 | 0% helix, 0% strand | P11077 |
| S, D, E, F, M, N, O, G, H, I | major capsid surface protein sigma-3 | protein | 365 | 0% helix, 0% strand | P07939 |
| U | guanylyltransferase | protein | 1284 | 0% helix, 0% strand | P11079 |
| V | major core protein lambda 1 | protein | 1031 | 0% helix, 0% strand | Q9WAB2 |
| W | major core protein lambda 1 | protein | 1221 | 0% helix, 0% strand | Q9WAB2 |
| X, Y, Z | Sigma 2 protein | protein | 417 | 0% helix, 0% strand | P11314 |
| 1 | Minor core protein lambda 3 | protein | 1264 | 0% helix, 0% strand | P17376 |
Pockets
20 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.44 | 0.72 | 38 | empty |
| 2 | 139 | 0.42 | 0.73 | 38 | empty |
| 3 | 130 | 0.41 | 0.73 | 36 | empty |
| 4 | 117 | 0.39 | 0.73 | 35 | empty |
| 5 | 120 | 0.39 | 0.73 | 30 | empty |
Interfaces
52 interfaces between chains.
- P–R · 791 Ų buried · 0 hydrogen bonds · protein-protein
- V–W · 774 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 726 Ų buried · 0 hydrogen bonds · protein-protein
- K–L · 704 Ų buried · 0 hydrogen bonds · protein-protein
- J–L · 704 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2CSE · Features of reovirus outer-capsid protein MU1 revealed by electron and image… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11077
- Every structure of UniProt P07939
- Every structure of UniProt P11079
- Every structure of UniProt Q9WAB2
- Every structure of UniProt P11314
- Every structure of UniProt P17376
- Elsewhere: RCSB PDB 2CSE · PDBe 2CSE · UniProt P11077 · UniProt P07939 · UniProt P11079 · UniProt Q9WAB2 · UniProt P11314 · UniProt P17376
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