Research workbench
Structure, refinement and function of carbonic anhydrase isozymes. refinement of human carbonic anhydrase I
Analyse Structure, refinement and function of carbonic anhydrase isozymes. refinement… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2CAB
- Type
- protein
- Length
- 256 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2
- Source
- Homo sapiens
- Molecule
- Carbonic anhydrase form B
- EC
- 4.2.1.1
- UniProt
- P00915
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · resolution 2 · 1 distinct chain · 16% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carbonic anhydrase form B (EC 4.2.1.1) | protein | 256 | 16% helix, 32% strand | P00915 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.52 | 0.80 | 21 | empty |
| 2 | 72 | 0.37 | 0.77 | 14 | empty |
Compared structures
- 2CAB · Structure, refinement and function of carbonic anhydrase isozymes. refinement of human… · the same entry in another collection · chain A against A, TM-score 1.00
- P00915 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 1 (P00915) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00915
- Elsewhere: RCSB PDB 2CAB · PDBe 2CAB · UniProt P00915
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