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Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei
Analyse Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B4V
- Type
- protein
- Length
- 437 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.8
- Source
- Trypanosoma brucei
- Molecule
- RNA editing complex protein MP57
- UniProt
- Q86MV5
- Ligands
- K
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · resolution 1.8 · 1 distinct chain · 47% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA editing complex protein MP57 | protein | 437 | 47% helix, 15% strand | Q86MV5 |
Ligands and binding sites
- K · Potassium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 603 | 0.70 | 0.79 | 52 | empty |
| 2 | 67 | 0.36 | 0.78 | 18 | K |
Modifications
Observed in the structure: 15 modified (engineered).
Compared structures
- 2B4V · Structural basis for UTP specificity of RNA editing tutases from trypanosoma brucei · the same entry in another collection · chain A against A, TM-score 1.00
- Q86MV5 · AlphaFold monomer V2.0 prediction for terminal uridylyltransferase 2 (Q86MV5) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86MV5
- Elsewhere: RCSB PDB 2B4V · PDBe 2B4V · UniProt Q86MV5
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