Research workbench
Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed with AzoAdoMet
Analyse Encephalitozooan cuniculi mRNA Cap (Guanine-N7) Methyltransferasein complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z3C
- Type
- protein
- Length
- 252 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.2
- Source
- Encephalitozoon cuniculi
- Molecule
- mRNA CAPPING ENZYME
- EC
- 2.1.1.56
- UniProt
- Q8SR66
- Ligands
- SA8
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · resolution 2.2 · 1 distinct chain · 38% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | mRNA CAPPING ENZYME (EC 2.1.1.56) | protein | 252 | 38% helix, 27% strand | Q8SR66 |
Ligands and binding sites
- SA8 · S-5'-azamethionine-5'-deoxyadenosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 454 | 0.65 | 0.78 | 44 | SA8 |
| 2 | 52 | 0.35 | 0.79 | 13 | empty |
| 3 | 59 | 0.34 | 0.77 | 11 | empty |
| 4 | 50 | 0.30 | 0.77 | 15 | empty |
Compared structures
- 1Z3C · Encephalitozooan cuniculi mRNA cap (guanine-N7) methyltransferasein complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8SR66 · AlphaFold monomer V2.0 prediction for mRNA cap guanine-N7 methyltransferase (Q8SR66) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8SR66
- Elsewhere: RCSB PDB 1Z3C · PDBe 1Z3C · UniProt Q8SR66
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